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pentobarbital will reduce the level or impact of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to a decrease in fentanyl plasma concentrations, not enough efficacy or, perhaps, enhancement of a withdrawal syndrome in a affected

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